📃 Paper Title: Silodosin to facilitate passage of ureteral stones: a multi-institutional, randomized, double-blinded, placebo-controlled trial.
🧍 Author: Sur
🕒 Year: 2014
📚 Journal: European Urology
🌎 Country: U.S.A.
ㅤContext to the study:
Name a paper that supports the use of a-blockers for distal ureteric stones, or larger stones.
ㅤ✅ Take-home message of study:
Data from the multicentre RCT suggest a-blockers may have a role in distal ureteric stones, or larger stones.
Patients should nonetheless be counselled on a-blocker use as it is unlicensed in the UK and comes with side effects.
Should be interpreted with caution given the small sample size and imaging techniques (US KUB)
ㅤ A Multi-institutional, Randomized, Double-blinded, Placebo-controlled Trial
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Study participants:
239 participants (6 discontinued due to side effects)
Follow-up period = 4 weeks
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Key study outcomes:
No significant differences between silodosin and placebo was observed for passage rate of all stones (52% vs 44%, respectively; p = 0.2)
However, silodosin had a significantly greater rate of distal ureter stone passage than placebo (69% vs 46%, p = 0.01).
No difference in return to ED, hospital re-admission or analgesia use
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Study Limitations:
Sample sizes not powered for subgroup analysis of distal stones
Intention to treat population smaller than planned sample size
US KUB used to detect stone persistence
No assessment of quality of life
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